English to Russian Medical Medical: Pharmaceuticals

Role of von Willebrand Factor
FVIII in nature circulates in plasma as a complex with VWF, of which FVIII represents only 1 to 2% in mass.
VWF is a crucial component of hemostasis and plays a key role in FVIII function, production, and stabilization.
In addition, it has been proposed that VWF may modulate FVIII immunogenicity via epitope masking, *blocking the presentation of FVIII to the immune system*, and thus may influence ITI outcome.